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New devices may offer painless blood sugar tests

By Anthony J. Brown, MD

NEW YORK (Reuters Health) - US and Australian researchers have come up with painless methods of checking blood sugar levels that could one day replace the finger pricks all too familiar to people with diabetes, according to reports at the annual scientific meeting of the American Diabetes Association in Orlando, Florida.

The method developed by the US group relies on the analysis of gases exhaled in the breath, whereas the test developed by the Australian team measures changes in the skin surface. At this point, however, both tests are in the early stages of development and are not immediately available.

"Some people claim that finger sticks are not that bad, but we've done some screening studies and found that many children do not want such sticks," Dr. Pietro Galassetti, lead researcher of the US team, told Reuters Health. "So an easy-to-use, (painless) method of measuring blood glucose would be an advance."

Using sophisticated analytical techniques, Galassetti's team, from the University of California at Irvine, was able to measure very low levels of gases that were exhaled by 10 volunteers during a special blood sugar test.

"We looked at levels of about 80 different gases present in exhaled breath," Galassetti said. "The two that best correlated with (sugar levels) were ethanol and acetone." Using these compounds, we were able to predict the subjects' blood sugar levels with a fair degree of certainty, he added.

Larger studies are needed to determine how practical this technique will be for the average diabetic patient, Galassetti said. At present, he said his group is working alone without any corporate sponsorship.

In the second study, Dr. Nejhdeh Ghevondian and colleagues, from AiMedics Ltd. in Sydney, Australia, tested the ability of a device they developed called HypoMon to detect low sugar levels in patients with type 1 diabetes. Although most people think of diabetics as having sugar levels that are too high, low sugar levels (or hypoglycemia) can be a life-threatening problem in such patients.

The device consists of a chest-belt transmitter that continuously monitors subtle changes in the skin. This transmitter then sends the data to a hand-held receiver that actually "learns" the changes characteristic of hypoglycemia.

In a small group of diabetic patients and healthy subjects, HypoMon detected the actual blood glucose level with a high degree of accuracy.

Further studies are underway to validate the device's use in detecting sugar levels that fall too low during sleep, the authors note.

 

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